A complete mail back disposal system for simplified management of bio hazardous waste. Approved for return in all 50 states US Territories by the United States Postal Service (USPS), the systems include a red OSHA-compliant sharps collection container, return shipping box, tracking manifest, instructions for use, and pre-paid return postage. When ready for disposal, the sharps container is placed in the pre-paid postage return box and returned to Sharps for treatment.